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Nanocomposites 3D à base de graphène fonctionnels greffés par des nanoparticules greffées en sandwich pour des biocapteurs de haute performance destinés à la détection de la biomolécule d'acide ascorbique.

Nous présentons un nano-biocapteur hautement sensible et sélectif pour la détection rapide, stable et hautement reproductible de l'acide ascorbique (AA) en présence de dopamine, d'acide urique et d'autres interférences par un arrangement en sandwich à trois couches de fonctions fonctionnalisées dopées à l'azote. nanocomposite de graphène (NFG), de nanoparticules d’argent (AgNPs) et de polyaniline nanostructurée (PANI). Les propriétés électrochimiques AA améliorées de l’électrode NFG / AgNPs / PANI sont attribuées à la conductivité supérieure du NFG-PANI et à l’excellente activité catalytique des AgNP. La modification critique de la NFG-PANI greffée avec AgNPs appliquée sur une électrode en oxyde d'étain dopée au fluor (FTOE) à très bas coût a augmenté la conductivité de transfert de charge de l'électrode (la résistance est tombée de 11 000 Omega à 6 Omega). Le nano-biocapteur a été utilisé pour détecter avec précision les AA dans des comprimés de vitamine C avec une récupération de 98%. Le capteur a démontré une limite de détection basse de 8 μM (S / N = 3) avec une très large plage de détection linéaire de 10 à 11 460 μM, une bonne reproductibilité et une excellente performance de sélectivité pour la détection des AA. Les résultats démontrent que ce nanocomposite est un candidat prometteur pour la détection rapide et sélective de l'AA dans des échantillons cliniques pratiques.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30718545


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