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La consommation de café infusé peut empêcher la réduction des niveaux de glutathion et d'acide ascorbique dans les lentilles chez les animaux nourris au HFD.

Le cristallin contient de fortes concentrations de glutathion (GSH) et d’acide ascorbique (AsA) afin de maintenir l’activité rédox et de prévenir la formation de cataracte, principale cause de déficience visuelle au monde. Le syndrome métabolique serait associé à un risque plus élevé de cataracte liée à l’âge. Comme il avait été démontré précédemment que la consommation de café améliorait les symptômes métaboliques induits par un régime alimentaire riche en graisses, il a été émis l’hypothèse que la consommation de café pourrait retarder l’apparition de la cataracte liée à l’obésité; Cependant, l'effet de la consommation de café sur ce type de cataracte reste inconnu. Des souris mâles C57BL / 6JJms SLC âgées de quatre semaines ont été divisées en deux groupes et ont été autorisées à accéder, à volonté, à un régime témoin (groupes témoins) ou à un régime HFD (groupes HFD). Les groupes de contrôle et les groupes HFD ont ensuite été divisés en trois ou quatre sous-groupes pour chaque expérience. La consommation de café a nettement réduit l’augmentation du poids corporel en fonction du temps de torréfaction et de la concentration. La consommation de café a également empêché la diminution de la concentration de GSH et d'AsA induite par l'HFD, et un traitement au pyrocatéchol ou à la caféine a également rétabli la réduction des composés antioxydants. Le cholestérol plasmatique et les triglycérides étaient significativement plus élevés dans les groupes HFD; Cependant, le traitement du café ou du café en infusion dans le groupe souris nourries avec HFD a empêché l'élévation de ces niveaux. La caféine est un composant majeur du café et le pyrocatéchol est généré par le processus de torréfaction. Ces résultats ont révélé que la caféine et le pyrocatéchol dans l’infusion de café pourraient être les principaux éléments responsables de la prévention de la réduction du GSH et de l’AsA chez les animaux nourris au HFD.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30680023


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