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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Réduction de la concentration d'acide ascorbique dans l'humeur aqueuse chez les femmes dont la profondeur de la chambre antérieure est inférieure.

La faible profondeur de la chambre antérieure est considérée comme un facteur de risque de perte de cellules endothéliales après phacoémulsification. Cependant, qu’il s’agisse ou non d’un facteur de risque indépendant reste controversé. Nous avons étudié la relation entre les concentrations d'acide ascorbique (AA) dans l'humeur aqueuse (AqH) et l'ACD. Nous avons analysé 165 échantillons AqH de 97 patients (42 hommes et 55 femmes) ayant subi une petite chirurgie de la cataracte par incision. Les concentrations d'AqH et d'AA plasmatiques ont été mesurées à l'aide d'une méthode de détection électrochimique par chromatographie en phase liquide à haute performance. Les caractéristiques des patients ont été comparées entre les sexes. En conséquence, l'âge et le DAC étaient significativement corrélés aux concentrations d'AqH AA (r = -0,206, P = 0,045; r = 0,339, P <0,001) uniquement chez les femmes. De plus, les concentrations plasmatiques d'AA étaient corrélées de manière significative avec les concentrations d'AqH AA (r = 0,420, P <0,001; r = 0,316, P = 0,002) chez les hommes et les femmes. Après ajustement pour tenir compte des facteurs de confusion (concentrations plasmatiques en âge et en AA), l'ACD était corrélé de manière significative et positive aux concentrations en AA AqH (partiel = 0,275, p = 0,009) uniquement chez les femmes. En conclusion, les concentrations d'AaH AA ont été réduites chez les femmes présentant un DAA plus petit. Cela peut suggérer que les femmes avec un DAA court pourraient être plus susceptibles aux dommages oxydatifs.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30674957


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