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Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 315
Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
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Filename: Session/Session.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
Line: 315
Function: require_once
Le but de cette étude était de concevoir un système nanocarburant pour l'administration par inhalation de rifampicine (RIF) en association avec de l'acide ascorbique (ASC), à savoir constitué d'alginate de sodium enrobé de chitosan et de Tween 80 (RIF / ASC NP) plate-forme pour le traitement de l'infection tuberculeuse pulmonaire. Un plan expérimental de Box-Behnken et une méthodologie de surface de réponse (RSM) ont été appliqués pour élucider et évaluer les effets de plusieurs facteurs sur les propriétés des nanoparticules. Par ailleurs, il a été constaté que les NP RIF / ASC étaient moins cytotoxiques que le RIF libre, montrant une activité significativement améliorée contre neuf souches cliniques de Mycobacterium tuberculosis (M. tb) par rapport au médicament libre. Les NP des RIF / ASC avaient une taille de particule moyenne de 324,0 ± 40,7 nm, un indice de polydispersité de 0,226 ± 0,030 et un potentiel zêta de - 28,52 ± 0,47 mV et la surface était hydrophile. L'ajout de saccharose (1% p / v) à la nanosuspension a entraîné la formation d'un culot solide facilement redispersable après lyophilisation. Les NP RIF / ASC se sont révélés stables à différentes valeurs de pH physiologiques. En résumé, les résultats de ces travaux soulignent le potentiel de la formulation de la formulation à base de NP RIF / ASC à délivrer ici, RIF en association avec la voie pulmonaire, en explorant une voie d'administration non invasive de cet antibiotique, augmentant les concentrations de tissus pulmonaires, le site de l'infection primaire, ainsi que réduire le risque de toxicité systémique et donc d'améliorer l'observance du patient.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30627867