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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
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Line Number: 292

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
Line: 315
Function: require_once

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Filename: drivers/Session_files_driver.php

Line Number: 166

Backtrace:

File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
Line: 315
Function: require_once

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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php

Line Number: 315

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/index.php
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Function: __construct

File: /home/orthodiedw/nutridatabase/index.php
Line: 315
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Le dérivé d'acide ascorbique DDH-1 améliore les lésions cutanées de type psoriasis chez la souris en supprimant l'expression des cytokines inflammatoires.

Le psoriasis est une maladie cutanée inflammatoire chronique dans laquelle les cytokines inflammatoires jouent un rôle majeur dans sa pathogenèse. Comme il a été récemment démontré que DDH-1, un nouveau dérivé amphipathique d'acide ascorbique, réduisait l'expression de cytokines inflammatoires dans les kératinocytes humains, nous avons étudié son effet sur les lésions cutanées de type psoriasis induites par l'imiquimod chez les souris C57BL / 6. Nous avons d’abord constaté que l’expression d’ARNm d’IL-1 bêta et de TNF-alpha était significativement réduite dans les lésions cutanées traitées avec DDH-1. En outre, l'administration cutanée de DDH-1 améliorant les lésions cutanées analogues à celles du psoriasis. Ces résultats suggèrent que la DDH-1 pourrait être efficace dans la prévention et le traitement complémentaire du psoriasis.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30503675


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