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Hydrocortisone, acide ascorbique et thiamine (traitement THA) pour le traitement de la sepsie. Concentrez-vous sur l'acide ascorbique.

Le sepsis est une maladie dévastatrice qui fait des victimes énormes en termes de souffrance humaine et de vies perdues. Plus de 100 nouveaux agents pharmacologiques ciblant des molécules ou des voies spécifiques n'ont pas réussi à améliorer l'issue de la septicémie. Les données préliminaires suggèrent que la combinaison de l'hydrocortisone, de l'acide ascorbique et de la thiamine (traitement contre la THA) pourrait réduire la défaillance d'organes et la mortalité chez les patients présentant un sepsis et un choc septique. La thérapie THA repose sur le concept selon lequel une combinaison d'agents facilement disponibles, sûrs et bon marché, qui ciblent plusieurs composants de la réponse de l'hôte à un agent infectieux, rétablira de manière synergique la réponse immunitaire dérégulée, ce qui empêchera ainsi la défaillance et la mort d'un organe. Cet article examine les raisons pour lesquelles un traitement contre la THA est axé sur la vitamine C.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30441816


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