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Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Line: 7
Function: __construct
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Cette étude a examiné la puissance et l'efficacité de l'acide ascorbique (AA) dans la gestion d'un comportement semblable à la dépression chez le rat diabétique. Le diabète sucré a été provoqué par des injections intraperitoneales uniques de nicotinamide (120 mg / kg) et de streptozotocine (65 mg / kg) administrées à 15 minutes d’intervalle. Des rats diabétiques (glycémie ≥ 250 mg / dL) ont été soumis à des chocs intermittents du pied pour induire une dépression concomitante. Sept groupes de rats diabétiques atteints de dépression comorbide ont reçu le véhicule (1 mL / kg) ou l'AA (10, 25, 50, 100, 200 ou 400 mg / kg) par voie orale pendant onze jours. Trois groupes de contrôle, à savoir les rats non diabétiques, diabétiques et déprimés ont reçu les véhicules uniquement. La puissance (DE50) et l'efficacité (Emax) de l'AA contre la période d'immobilité, l'hypercorticostéronémie, l'hyperplasie surrénalienne, l'hyperglycémie, l'hypoinsulinémie, le stress oxydatif et la réponse inflammatoire ont été estimés. L'administration d'AA a entraîné une diminution liée à la dose (p <0,05) de la période d'immobilité avec une inhibition maximale de 69% (efficacité) à 200 mg / kg et une DE50 de 14 mg / kg (activité). Un AA à 200 mg / kg a entraîné la réduction maximale de l'hypercorticosteronémie (55,1%) et de l'hyperplasie surrénalienne (52,6%) avec une DE50 de 9,8 et 14,4 mg / kg, respectivement. Un AA à 400 mg / kg a entraîné la réduction maximale de l'hyperglycémie (35,5%), de l'hypoinsulinémie (32,7%) et de la peroxydation lipidique (82%) avec un DE50 de 18,6, 13,7 et 20,7 mg / kg, respectivement. De plus, les AA à 400 mg / kg ont entraîné l'augmentation maximale de la teneur en SOD (83%), de l'activité de la CAT (77,9%) et du niveau d'IL-10 (63%) avec une DE50 de 21,5, 21 et 21 mg / kg, respectivement. . En conclusion, les présents résultats suggèrent que les AA ont un potentiel thérapeutique contre la dépression concomitante avec le diabète, mais une meilleure régulation de l'hyperglycémie et de l'hypoinsulinémie est nécessaire pour obtenir des bénéfices maximaux.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30399569