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Les métabolites de l'acide ascorbique sont impliqués dans le contrôle de la pression intraoculaire dans la population générale.

Une pression intraoculaire élevée (PIO) est un facteur de risque important du glaucome. Les mécanismes impliqués dans l'homéostasie ne sont pas bien compris, mais des associations entre les facteurs métaboliques et la PIO ont été rapportées. Pour étudier la relation entre les niveaux de métabolites circulants et la PIO, nous avons effectué une association à l'échelle du métabolome à l'aide d'un algorithme d'apprentissage automatique, puis nous avons utilisé des modèles de randomisation mendélienne pour explorer plus en détail la force et la directionnalité des effets des métabolites sur la PIO. Nous montrons que l’O-méthylascorbate, un métabolite circulant de la vitamine C, a un effet significatif de réduction de la PIO, conformément aux connaissances antérieures sur le rôle anti-hypertenseur et anti-oxydant des composés de l’ascorbate. Ces résultats améliorent la compréhension du contrôle de la PIO et pourraient éventuellement bénéficier à un traitement ultérieur de la PIO et réduire la perte de vision due au glaucome.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30391827


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