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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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L'acide ascorbique, les corticostéroïdes et la thiamine dans le sepsis: examen de la logique biologique et de l'état actuel de l'évaluation clinique.

La combinaison de thiamine, d'acide ascorbique et d'hydrocortisone est récemment apparue comme traitement adjuvant potentiel aux antibiotiques, de contrôle des sources infectieuses et de soins de soutien pour les patients atteints de sepsis et de choc septique. Dans le présent manuscrit, nous fournissons une revue complète de la base physiopathologique et soutenons la recherche pour chaque élément de l'association thiamine, acide ascorbique et hydrocortisone dans le sepsis. En outre, nous décrivons les domaines de synergie potentiels entre ces thérapies et discutons des forces / faiblesses des deux études menées à ce jour qui ont évalué la combinaison de médicaments chez des patients présentant une infection grave. Enfin, nous décrivons l’état actuel de la pratique clinique en ce qui concerne la combinaison thiamine, acide ascorbique et hydrocortisone et présentons un aperçu de l’acide ascorbique multicentrique, randomisé, contrôlé par placebo, et de la thiamine dans Sepsis (ACTS). ) essai et autres essais cliniques randomisés planifiés / en cours.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30373647


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