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Filename: drivers/Session_files_driver.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
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Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Function: __construct
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Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
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Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 315
Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Line: 7
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Filename: Session/Session.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
Line: 315
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Les interactions pharmacodynamiques de trois antibiotiques anthracyclines, à savoir la doxorubicine (DXH), l’épirubicine (EpiDXH) et la daunorubicine (DNR) avec l’ADN en présence et absence d’acide ascorbique (AA) en tant qu’additif naturel ont été surveillées dans des conditions physiologiques (pH = 7,4, 4,7 et T = 309,5K). La Route-1 (Anthracycline-AA-ADN) et la Route-2 (Anthracycline-ADN-AA) ont été adoptées pour observer le comportement interactionnel par voltamétrie cyclique (CV) et spectroscopie UV-visible. En comparaison avec Route-2; Les réponses voltamétriques et spectrales ainsi que les valeurs de constante de liaison (Kb) et de changement d'énergie libre de Gibb (DeltaG) ont révélé une interaction plus forte et plus favorable du complexe anthracycline-AA avec l'ADN via la Route-1. Kb, s (taille des sites de liaison) et DeltaG évalués à partir de résultats expérimentaux (CV, UV-Vis) et théoriques (ancrage moléculaire) ont montré une force de liaison accrue des complexes tertiaires par rapport aux complexes médicament binaire-ADN. Les résultats ont été trouvés comparativement meilleurs à pH 7,4. La cohérence a été observée dans les paramètres de liaison évalués à partir de techniques expérimentales et théoriques. Les coefficients de diffusion (Do) et la constante de vitesse de transfert d'électrons hétérogène (ks, h) ont confirmé la formation de complexes via une cinétique de diffusion lente. Le pourcentage d'inhibition cellulaire (% Cinh) d'anthracyclines pour les lignées cellulaires cancéreuses non à petites cellules (NSCCL) H-1299 et H-157 a été évalué plus élevé en présence d'AA, complétant ainsi les résultats expérimentaux et théoriques.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30372448