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Filename: drivers/Session_files_driver.php
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Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Les dyslipidémies se produisent plus tôt dans la population en raison de l'augmentation de l'obésité. La rosuvastatine réduit le cholestérol et les triglycérides; Cependant, des études antérieures ont montré que cela peut affecter la reproduction masculine. L'acide ascorbique (AA), un composé antioxydant, joue un rôle protecteur dans le système reproducteur masculin. Cette étude visait à évaluer si l'exposition pré-pubère à la rosuvastatine pouvait altérer la structure testiculaire et le statut antioxydant chez le rat mâle et si une supplémentation en AA pouvait atténuer ces dommages. Les rats mâles ont été divisés au hasard en six groupes expérimentaux (n = 10) le jour postnatal 23 et ont reçu les différents traitements par gavage de 23 à 53 jours. Les groupes expérimentaux ont reçu le véhicule (solution saline 0,9%), 3 ou 10 mg / kg / jour de rosuvastatine diluée dans une solution saline à 0,9%, supplémentation avec 150 mg / jour d'AA, 3 mg / kg / jour de rosuvastatine en association avec 150 mg / jour d'AA ou 10 mg / kg / jour de rosuvastatine associée à 150 mg / jour de AA. Les paramètres testiculaires ont été évalués sur les PND 53 et 110. Il y avait une diminution de la coloration des récepteurs des androgènes dans les cellules de Sertoli et une augmentation de la mort des cellules germinales dans les groupes exposés à la rosuvastatine, au cours des deux périodes. Les spermatides ont présenté une coloration inférieure des récepteurs alpha-œstrogéniques dans le groupe exposé à 10 mg de statine à l'âge adulte. Il y avait une déplétion en androgènes et une augmentation de la peroxydation des lipides et de l'activité de la catalase chez les groupes exposés aux statines. L'exposition à la rosuvastatine pendant la pré-puberté a altéré la structure testiculaire, la distribution des récepteurs de stéroïdes et l'augmentation du stress oxydatif; Cependant, AA a pu améliorer la déficience provoquée par l'exposition aux statines.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30240002