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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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Sonde bifonctionnelle fluorescente et photoacoustique pour la détection de l'acide ascorbique dans les fluides biologiques, les cellules vivantes et in vivo.

L'imagerie photoacoustique (PAI) est devenue une technologie clinique prometteuse grâce à sa haute résolution dans les tissus profonds. Cependant, le manque de spécificité vis-à-vis des analytes limite l'application ultérieure de la sonde PA en imagerie moléculaire. À cette fin, nous rapportons ici une sonde bimodale de PA et de fluorescence (FL) pour la détection sélective de l'acide ascorbique (AA). Pour réaliser cette conception, l'oxyhydroxyde de cobalt (CoOOH) a été adopté comme plate-forme multifonctionnelle (agent de contraste pour PA, agent d'extinction de FL et oxydant spécifique pour AA) et hybride avec des points de carbone émettant du rouge (RCD). En présence d'AA, CoOOH est réduit en Co2 + et, dans l'intervalle, libère des DDR, entraînant la diminution de l'AP et la récupération des signaux FL. Nous avons démontré les capacités de détection de l'AA de la sonde dans les fluides biologiques complexes (sérum et urine humains), les cellules vivantes et l'imagerie bimodale FL / PA in vivo. Ce travail a révélé pour la première fois la capacité PAI de CoOOH, ce qui pourrait inspirer les chercheurs à concevoir d'autres sondes PA basées sur CoOOH et à utiliser davantage de DDR en biologie et en clinique.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30221263


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