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L'acide ascorbique conduit à la glycation et interfère avec la croissance des neurites.

L'acide ascorbique, mieux connu sous le nom de vitamine C, est un glucide réducteur nécessaire à diverses fonctions du corps humain. La caractéristique la plus importante de l’acide ascorbique est la capacité de donner deux électrons, le prédestinant en tant qu’acteur majeur dans l’équilibrage de l’état rédox physiologique et en tant que cofacteur nécessaire dans de multiples processus d’hydroxylation enzymatique. L'acide ascorbique peut être oxydé de manière réversible en deux étapes, conduisant respectivement à l'acide semidéhydroascorbique et à l'acide déhydroascorbique. Une dégradation supplémentaire est irréversible et génère des intermédiaires carbonyle hautement réactifs. Ces intermédiaires sont capables d'induire la glycation de protéines, une réaction non-enzymatique et non spécifique de carbonyles avec des groupes amino impliqués dans plusieurs maladies liées à l'âge. Dans cette étude, nous avons étudié l'effet de la glycation induite par la glycation induite par l'acide ascorbique et l'acide déshydroascorbique sur les cellules PC12, qui représentent un modèle de plasticité neuronale. Nous avons constaté que les deux applications d'acide ascorbique ou déhydroascorbique conduisent à la glycation de protéines cellulaires, mais que l'acide ascorbique interfère davantage avec la viabilité et la croissance des neurites que l'acide déhydroascorbique.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30149062


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