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Points de carbone provenant des sucres et de l'acide ascorbique: rôle des précurseurs dans la morphologie, les propriétés, la toxicité et l'absorption de médicaments.

Des protocoles synthétiques reproductibles, simples et à haut rendement sont nécessaires pour obtenir des points de carbone (CD) à fluorescence contrôlée, comportement photothermique et photochimique, propriétés de surface, biocompatibilité, capacité de ciblage de la tumeur, biodistribution par absorption de médicament et absorption par la tumeur. . Cette lettre décrit une étude systématique sur l’effet du glucose, du fructose et de l’acide ascorbique en tant que produits de départ pour la préparation de CD hautement luminescents, caractérisés par une émission bleue. Leur composition et leur morphologie sont étudiées par titration de groupes de surface OH, par des techniques spectroscopiques et par microscopie électronique à transmission à haute résolution (HR-TEM), et leur toxicité a été testée pour les cellules HeLa. Les CD fabriqués à base de fructose étaient toxiques, tandis que ceux à base de glucose et d'acide ascorbique présentaient une bonne biocompatibilité. La procédure synthétique simple et reproductible produit des CD luminescents dérivés de la biomasse pour une thérapie anticancéreuse combinée et des diagnostics. Leur absorption de médicament à la doxorubicine (DOX) a été mesurée par spectrofluorimétrie, indiquant un rôle crucial des morphologies des CD dans le contrôle de la charge en DOX. Les CD dérivés du glucose montraient jusqu'à 28% en poids de charge en DOX.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30128076


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