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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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L'acide ascorbique abaisse la pression artérielle centrale et la diméthylarginine asymétrique dans les cas d'insuffisance rénale chronique.

Contexte: Les facteurs de risque traditionnels ne peuvent expliquer la maladie cardiovasculaire prématurée chez les patients atteints d'insuffisance rénale chronique (IRC) et le stress oxydatif peut y contribuer via un dysfonctionnement endothélial et vasculaire. Nous avons étudié l’effet de l’acide ascorbique sur le stress oxydatif et la fonction vasculaire chez les patients atteints de néphropathie chronique par rapport aux témoins hypertendus (HTN). Méthodes: Une étude croisée de la solution saline intraveineuse et de l'acide ascorbique a été menée. Les biomarqueurs du stress oxydatif ont été mesurés, tandis que l'analyse par onde de pouls et la dilatation induite par le flux brachial ont été réalisées pour évaluer la fonction des grandes artères et de l'endothélium. Résultats: Vingt patients atteints de HTN et 30 atteints d'insuffisance rénale chronique ont été recrutés aux étapes 3-5. L’acide ascorbique sérique était significativement plus faible chez les patients atteints d’IRC. Dans les deux groupes, l'acide ascorbique augmentait significativement le potentiel antioxydant total et le superoxyde. La diméthylarginine asymétrique (ADMA) a été réduite de manière significative par l’acide ascorbique dans le groupe CKD et lors d’une analyse de régression multivariée, l’âge et la présence de CKD étaient des facteurs prédictifs de la réponse de l’ADMA à l’acide ascorbique. Bien qu'aucun effet sur la fièvre aphteuse n'ait été observé, la pression artérielle centrale et l'indice d'augmentation ont été réduits de manière significative dans les deux groupes. Conclusions: L'acide ascorbique a des effets pro- et antioxydants, réduisant la pression artérielle centrale et l'indice d'augmentation du HTN et de l'IRC. L'acide ascorbique réduit l'ADMA sérique dans l'IRC, ce qui peut avoir des avantages à long terme.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30094018


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