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Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: require_once
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Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Function: __construct
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Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
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Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 315
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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Line: 7
Function: __construct
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Filename: Session/Session.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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Backtrace:
File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
Line: 315
Function: require_once
Les dyslipidémies se produisent plus tôt dans différents pays en raison de l'augmentation de l'obésité, des mauvaises habitudes alimentaires et du style de vie sédentaire. La rosuvastatine réduit le cholestérol sérique; Cependant, plusieurs études ont associé l'exposition aux statines à une altération de la reproduction chez l'homme. L'acide ascorbique (AA) est une substance antioxydante qui joue un rôle protecteur dans le système reproducteur masculin. Les rats mâles ont été répartis au hasard en 6 groupes expérimentaux (n = 10), qui ont reçu une solution saline à 0,9%, 3 ou 10 mg / kg / jour de rosuvastatine, 150 mg / jour d'AA ou 3 ou 10 mg / kg / jour de rosuvastatine. associées à 150 mg / jour d'AA du jour postnatal 23 jusqu'à la 53e. À la 100e journée, les mâles ont été accouplés à des rats femelles non traités pour obtenir les chiots femelles. Le jour de l'ouverture vaginale et le premier estrus ont été évalués dans la progéniture. Deux groupes de femmes ont été euthanasiés lors du premier estrus après les PND 42 et 75 afin d'évaluer l'histologie des organes reproducteurs et les taux d'hormones. Un troisième ensemble a été utilisé pour le test de comportement sexuel et de fertilité autour de 75 JAN. La progéniture des mâles exposés ou co-exposés à la dose plus élevée de statine présentait un nombre inférieur de corps jaunes pendant la puberté. À la maturité sexuelle, le groupe expérimental d'hommes exposés à 3 mg présentait une zone d'épithélium luminal utérin inférieur. L'exposition paternelle à la rosuvastatine à la pré-puberté a entraîné une diminution de l'épithélium luminal utérin chez la progéniture féminine, ce qui suggère que des modifications épigénétiques ont été initiées par la statine. L'acide ascorbique co-administré à des hommes prépubères a pu atténuer les dommages de la reproduction chez la progéniture des femelles de rat à l'âge adulte.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30081759