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Essai comparatif préliminaire randomisé des effets anti-vieillissement de l'acide l-ascorbique appliqué en association avec la mésothérapie sans aiguille et le microaiguille.

CONTEXTE: L'épiderme est un épithélium squameux stratifié kératinisé recouvert d'une barrière hydro-lipidique. La vitamine C est un antioxydant hydrosoluble qui protège la peau contre les dommages oxydatifs et régénère la peau photo-âgée. Il existe différentes options pour améliorer la pénétration de la substance active dans la couche cornée de l'épiderme. L'une d'entre elles est la mésothérapie sans aiguille, une technique de rajeunissement non invasive comportant des impulsions électriques, une électroporation et des ultrasons. L'utilisation de ces facteurs physiques entraîne une pénétration plus profonde des ingrédients actifs. L'autre est la mésothérapie aux micro-aiguilles qui est une thérapie non chirurgicale, qui pourrait provoquer une inflammation contrôlée. Les micro-canaux sont formés par des aiguilles lors de la ponction de la peau, ce qui facilite la pénétration des principes actifs. OBJECTIFS: Le but de l’étude était d’évaluer l’efficacité de l’acide L-ascorbique appliqué en association avec la mésothérapie sans aiguille et à la micro-aiguille dans le traitement anti-âge. Matériels et méthodes: Cette étude a été menée chez 17 volontaires en bonne santé. 2,5 ml de sérum contenant 20% d'acide L-ascorbique et de l'hydrate de fraise ont été utilisés par voie topique dans chacun des 4 traitements. Une mésothérapie sans aiguille a été appliquée sur la moitié gauche du visage, tandis qu'une mésothérapie à la micro-aiguille, associée au même sérum, a été réalisée sur la moitié droite du visage. Résultats: Des études in vivo ont confirmé l'efficacité des deux méthodes. CONCLUSION: L'impact de la substance active sur la fermeté et l'élasticité de la peau, ainsi que sur le degré d'hydratation et le tonus de la peau, a été plus efficace après la mésothérapie aux micro-aiguilles.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30070034


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