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Filename: drivers/Session_files_driver.php
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CONTEXTE ET OBJECTIFS: L'anémie nutritionnelle est un problème de santé publique important, avec une prévalence de 50 à 80% chez les enfants indiens. L'enrichissement des aliments, en particulier du lait, avec du fer est une approche potentielle pour augmenter l'apport en fer alimentaire. Le pyrophosphate ferrique [Fe4 (P2O7) 3] est organoleptiquement neutre et est moins soluble en milieu acide et, de plus, a une faible biodisponibilité dans le lait. Cependant, l’acide ascorbique étant un puissant activateur de l’absorption du fer, la coadministration de l’acide ascorbique avec Fe4 (P2O7) 3 pourrait augmenter l’absorption du fer. Nous avons évalué l'effet de l'acide ascorbique sur l'absorption du fer provenant d'un Fe4 (P2O7) 3 et d'une boisson lactée enrichie d'acide ascorbique par rapport au lait enrichi de Fe4 (P2O7) 3 seul. MÉTHODES ET CONCEPTION DE L’ÉTUDE: Une étude randomisée croisée à double insu et à double insu a été menée chez 25 enfants légèrement anémiques. Le groupe de test a reçu du lait enrichi avec une boisson en poudre contenant 7 mg de fer marqué à l'isotope (57Fe / 58Fe) sous forme de Fe4 (P2O7) 3, en proportions équimolaires d'acide ascorbique et de 200 mg de calcium, tandis que le groupe témoin a reçu du lait enrichi en énergie, en calcium et en fer. boisson en poudre. L'absorption fractionnelle du fer a été mesurée par incorporation dans les érythrocytes d'isotopes stables du fer (57 Fe / 58 Fe) dans les deux groupes. Résultats: L'absorption fractionnelle du fer provenant de la boisson témoin était de 0,80% (IC à 95%: 0,57, 1,12). En fortifiant le lait avec une quantité équimolaire d’acide ascorbique, l’absorption fractionnelle du fer a été multipliée par 2, atteignant 1,58% (IC à 95%: 1,13, 2,22). CONCLUSIONS: La présence d'acide ascorbique dans un rapport équimolaire avec celle du fer provenant du sel de Fe4 (P2O7) 3 dans le lait en tant que supplément fortifiant augmente l'absorption du fer par rapport au lait enrichi en Fe4 (P2O7) 3 seulement.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30045423