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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Le colon a ciblé des microsphères de curcumine chargées d'acide ascorbique pour améliorer la biodisponibilité.

Un des objectifs de la présente étude était de préparer des microsphères de curcumine (CUR) spécifiques du côlon contenant de l’acide ascorbique (AA) afin d’améliorer la biodisponibilité orale. La conception factorielle 3 (2) a été utilisée pour optimiser les microsphères de chitosane (CSMS) contenant CUR et AA. Par la suite, les CSMS optimisés ont été recouverts d'Eudragit S-100, en vue de leur administration au colon. Des études de libération in vitro de médicament, de pharmacocinétique in vivo et de distribution d'organes ont été menées chez des rats Albino Wistar. La stabilisation de la CUR dans un pH alcalin a été protégée avec succès par AA dans une mesure de 98,5 à 100%. Les résultats ont révélé une amorphisation complète / dispersion moléculaire de la CUR. L'amélioration de la biodisponibilité de la CUR et de 90% de la SEP dans le côlon au bout de 8 h chez les animaux a permis de déchiffrer la conception réussie de la CUR-MS spécifique du côlon. On peut en conclure que les AA dans les États membres protégeaient la dégradation de la CUR. La MS à double couche développée pourrait être considérée comme un système prometteur ciblant les améliorations de la biodisponibilité ciblée CUR.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30010458


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