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Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: require_once
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Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
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Filename: Session/Session.php
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Filename: Session/Session.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Le tabagisme cause une vaste gamme de maladies, notamment les maladies cardiovasculaires. Notre laboratoire se concentre sur les recherches sur les dysfonctionnements cardiovasculaires induits par la fumée de cigarette et sur les mécanismes responsables utilisant le modèle, les cellules souches cardiaques (CSC) c-kit positives. L’objectif principal de notre étude est d’étudier si les extraits de CS (CSE) causent une altération des fonctions du SCC via des dommages oxydatifs. Nous avons émis l’hypothèse que le CSE, via des modifications oxydatives des protéines CSC et des enzymes antioxydantes, peut moduler les fonctions CSC et que ces modifications peuvent être atténuées par le traitement à l’ascorbate. Nos objectifs spécifiques sont (1) d’étudier la modification oxydative des protéines CSC induite par la CSE via la carbonylation et la prévention par l’acide ascorbique; (2) d'étudier la modification oxydative induite par le CSE d'enzymes antioxydantes et les modulations médiées par l'acide ascorbique; et (3) étudier les modifications induites par le CSE dans les fonctions du SCC et la protection par l'acide ascorbique. Les CSC ont été cultivés et les extraits aqueux de CSE ont été préparés. Des modulations induites par le CSE de la viabilité du CSC, de la modification oxydante des protéines et des activités enzymatiques antioxydantes ont été détectées à l'aide d'analyses classiques comprenant Apostain, la bromodésoxyuridine et Oxiblot. Le CST a provoqué une modification oxydative des protéines CSC, une modification des niveaux d'enzyme antioxydante, une prolifération atténuée du CSC et une apoptose accélérée du CSC. L'acide ascorbique a permis d'éviter les dysfonctionnements du SCC induits par le CST, et une thérapie à l'acide ascorbique pourrait être utile chez les bénéficiaires du SCC fumeurs et pour conditionner les CSC avant la greffe à l'avenir. La thérapie par cellules souches cardiaques fait actuellement l'objet d'essais cliniques.
Source: https://www.ncbi.nlm.nih.gov/pubmed/30006751