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Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Function: require_once
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Filename: drivers/Session_files_driver.php
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Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
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Function: require_once
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Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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Filename: Session/Session.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
Line: 7
Function: __construct
File: /home/orthodiedw/nutridatabase/index.php
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La phase aiguë de la maladie de Chagas (CD) se caractérise par une prolifération parasitaire élevée et une inflammation intense, exacerbant la génération d'espèces réactives de l'oxygène (ROS) et d'espèces réactives de l'azote (RNS). Ces molécules réactives sont également augmentées par le métabolisme des composés nitrohétérocycliques benznidazole (BZ) et nifurtimox, les seuls médicaments disponibles pour le traitement de la MC. Cet environnement oxydant, associé à la multiplication intracellulaire de Trypanosoma cruzi, conduit à la destruction des tissus, déclenchant le processus pathogène. Les deux médicaments ont une efficacité limitée et des effets secondaires graves, ce qui démontre la nécessité de rechercher des thérapies alternatives. En raison de la difficulté à développer de nouveaux médicaments, la révision des schémas thérapeutiques semble avantageuse et l'utilisation de BZ à faibles doses associée à des antioxydants, tels que l'acide ascorbique (AA), constituerait une alternative valable pour atténuer le stress oxydatif. Dans nos études in vivo, des souris recevant la combinaison de 7,14 mg / kg de poids corporel / jour d’AA et de 10 mg / kg / jour de BZ10 (AA + BZ10) ont présenté une réduction de la parasitémie plus efficace que celle des souris recevant du BZ ou AA seul. Le traitement combiné a été efficace pour réduire les ROS intracellulaires et la peroxydation des lipides dans le tissu cardiaque. Les analyses histologiques et PCR ont montré que les AA réduisent également le parasitisme cardiaque. Cependant, le bénéfice le plus important a été observé dans le groupe AA + BZ10, l’inflammation cardiaque ayant été significativement réduite. En outre, la thérapie combinée a empêché les dommages hépatiques induits par l’infection. Nos résultats suggèrent que AA associé à une faible dose de BZ pourrait améliorer l'activité trypanocide et atténuer les effets toxiques du BZ. La diminution des dommages oxydatifs et de l'inflammation observée chez les souris traitées avec AA + BZ10 pourrait entraîner une cardioprotection accrue.
Source: https://www.ncbi.nlm.nih.gov/pubmed/29987143