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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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Filename: drivers/Session_files_driver.php

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File: /home/orthodiedw/nutridatabase/application/controllers/Articles.php
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File: /home/orthodiedw/nutridatabase/index.php
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Développement de nanoparticules phospholipidiques encapsulant de l'acide 3-O-cétyl ascorbique et de l'acétate de tocophérol (TA-Cassome) afin d'améliorer leur accumulation dans la peau.

Les nanoparticules phospholipidiques (PN) encapsulant les dérivés de vitamines C et E, l’acide 3-O-cétyl ascorbique (CA) et l’acétate de tocophérol (TA), respectivement, ont été examinés à l’aide de la méthode de réhydratation par film et d’extrusion. Les formulations de PN (TA-Cassome) ont été préparées en mélangeant de l'AC, de la phosphatidylcholine de soja (Soya PC), du cholate de sodium et de l'AT dans un rapport molaire de 20/80/5/6. Du glycérol (GL) ou du diglycérol (DG) ont également été ajoutés pour améliorer l'accumulation cutanée de CA et de TA. Trois formulations de TA-Cassome ont été évaluées à l'aide d'une analyse par diffusion dynamique de la lumière (DLS), RMN, TEM, d'accumulation cutanée pour CA et TA et d'une analyse par diffraction des rayons X à petit angle (SAXD). Les formulations de TA-Cassome (150 nm) sont restées stables pendant deux semaines et ont encapsulé 1,8 mg / mL de TA. Les analyses TEM et SAXD ont révélé que les nanoparticules formaient une structure multicouche sphérique. (1) H et (31) P RMN ont indiqué que GL et DG amélioraient la mobilité des protons des groupes choline des molécules de PC de soja situées à la surface de la membrane de TA-Cassome. L'accumulation de CA et de TA dans le derme a été augmentée en ajoutant GL et DG. L'analyse SAXD a révélé que GL et DG favorisaient la formation de nouvelles structures lamellaires sur la couche cornée, contribuant ainsi à améliorer l'accumulation de CA et de TA dans la peau.


Source: https://www.ncbi.nlm.nih.gov/pubmed/29906563


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