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Nouveau capteur électrochimique à base de nanochaines de platine auto-assemblées - Nanoparticules de carbone et de nanoparticules de graphène composites à parois multiples pour la détermination simultanée de la dopamine et de l'acide ascorbique.

Dans cette étude, des nanochains de platine (PtNC), des nanotubes de carbone à parois multiples (MWCNT) et des nanoparticules de graphène (GNP) ont été assemblés pour former un nouveau nanocomposite par un processus de fusion facilité assisté par ultrasons. Le nanocomposite PtNC-MWCNTs-GNP a été caractérisé par microscopie électronique à transmission à haute résolution (HR-TEM), spectroscopie à rayons X à dispersion d'énergie (EDS), microscopie à balayage électronique (SEM) et diffraction des rayons X (XRD). Le nanocomposite a été utilisé pour la modification de l'électrode en carbone de verre (GCE) et la détermination simultanée de la dopamine (DA) et de l'acide ascorbique (AA) par voltampérométrie différentielle par impulsions (DPV) et voltampérométrie cyclique (CV). Dans les conditions optimales, les courbes d’étalonnage obtenues sont linéaires pour les courants en fonction des concentrations de DA et de AA dans l’intervalle compris entre 2,00 et 50,0 µm et entre 100 et 1 200 µm. Et les limites de détection pour DA et AA sont respectivement de 0.500muM et 10.0muM. La détection et l’analyse quantitative de DA et d’AA dans le sérum humain et les comprimés de vitamine C sur PtNCs-MWCNT-GNP / GCE ont donné des taux de récupération de 104-110% et 101-108% avec des écarts types relatifs de 4.36-7.48% et 0,620 à 2,90%, respectivement. Le composite proposé PtNCs-MWCNTs-GNP pourrait fournir une nouvelle plate-forme pour l'analyse de routine des DA et des AA en termes de bonne capacité anti-ingérence, d'excellente reproductibilité et répétabilité, et de faisabilité d'utilisation.


Source: https://www.ncbi.nlm.nih.gov/pubmed/30708228


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